Silcream Cream-Salicifix

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Silver sulfadiazine

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Quantity Stength Unit Price Price Cart
1 Tube Silcream Cream $2.98 $2.98
3 Tube Silcream Cream $2.84 $8.53
6 Tube Silcream Cream $2.76 $16.54


Silcream comprises of Silver Sulfadiazine which is a main ingredient of this medicine. It is a sulfonamide which is used topically for the treatment of infections in burn wounds. It prevents against Gram-positive and Gram-negative bacteria as well as some yeast and fungi. It has a bactericidal action, and when this cream is applied on the skin produce painless effect and pleasant cooling effect to the burnt area. It is a better choice for the prevention of infection of burns.

Mechanism of action:

It acts mainly on the cell membrane and cell wall to dislocate its intergrity thus permitting it to damage the important enzymes. Then bacterial DNA and RNA lead to cell death. Silcream action is not antagonised by p-aminobenzoic acid.


  • It is contraindicated in persons who are oversensitive to sulfonamides.
  • Silcream is also contraindicated in pregnancy and breast feeding mothers.

Drug interaction:

It should not be given concurrently with Phenytoin and Tolbutamide because absorbed Sulfadiazine is a competitive blocker of enzymes in the hepatic metabolism of these drugs.

Storage condition: It should be stored below 25oC in a dry place, should be stay away from light. Store it away from the reach of children.

Dosage and administration:

It should be used as 1% cream topically. The cream should be applied one time or twice daily to a width of at about 1/16 inch. Firstly clean the burn wound and then apply Silcream on all the affected areas. Use a sterile glove hand for best results. If necessary, Silcream should be re-used to area from which this cream has been clear out by patient activity. It should be re-applied within 24 hours in burns, or more regularly if the size of broken tissue is large. Silcream is not prescribed in leg ulcer that is more affected burnt area.

Side effects of Silcream:

Some symptoms may develop while using Silcream such as allergic reactions likes burning, rashes, unusual bleeding, reduced platelets, itching, fever and leucopenia in patients who using Silver Sulfadiazine.

Precautions to be followed while using this cream: 

  • It should be used cautiously in person with damaged hepatic or renal function
  • It is necessary to maintain sufficient fluid and electrolyte intake.
  • Before using this cream you should check your blood counts or ask your doctor. You should not use this cream for longer period because systemic absorption of this cream resulting in argyria which may develop, if it is used to more affected wounds.
  • Avoid the use of this cream in infants below two months of age.
  • It should be used cautiously in patients with previous history of liver or renal disorder, any allergy.
  • Gently clean the affected burnt area regularly to help clean out dead skin.

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