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Brief overview about Cenforce 50mg

Cenforce is an orally administered drug used for the treatment of erectile dysfunction. Erectile dysfunction particularly refers to impotence problem when a male is not able to achieve satisfactory erection required at the time of physical intercourse with the partner. The active ingredient present in Cenforce is Sildenafil citrate which is responsible for the blood flow in the penile region.

Cenforce with an active ingredient Sildenafil citrate inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penile. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by Sildenafil enhances erectile function by increasing the amount of cGMP.

Dosage Information of Cenforce 50mg tablets:

Cenforce is available as 50mg extended release tablets to be taken 30-40 minutes orally with plenty amount of water before the planned intercourse and particularly with or without meals. These tablets should not be crushed or chewed; it should be swallowed as a whole.

Side-effects of Sildenafil Cenforce 50mg tablets:

  • Headache
  • Flushing
  • Dyspepsia
  • urinary tract infection
  • vision problems
  • diarrhea
  • dizziness
  • rashes
  • body ache
  • nausea
  • sore throat
  • stomach disturbance

Drug Interactions Cenforce 50mg tablets:

  • CYP3A4 and 2C9
  • Use of nitrates such as isosorbide, nitroglycerin
  • Alpha-adrenergic blockers and anti-hypertensive drugs

Precautions Should be taken while taking Sildenafil Cenforce 50mg tablets:

There are some precautionary measures to be kept in mind while using Cenforce such as;

  • Alcohol consumption should be avoided in order to avoid the adverse effects
  • Caution is advised while using this medication along with alpha blockers as it may cause sudden decline in blood pressure
  • Avoid use of grapefruit juice while using this medication
  • Patients suffering from serious cardiac disorders should use this medication with extreme caution as sexual activity is associated with potential cardiac risks
  • Patients suffering from sickle cell anemia and multiple myelomas should use this medicine only after the consultation with the doctor

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